I switched all of my grips to Midsize last year and couldn't be happier with them. I am 6 foot and I wear a small to cadet small/medium Titleist glove (though I like my glove tight). Since switching to the midsize I have been hitting the ball with more spin, slightly lower ball flight but more or less the same but maybe 5 yards further on average. I think it is more about what you like in terms of feel. I have used standard grips with multiple wraps and hatted the feel, but couldn't be happier with my midsized grips. Maybe try a midsized grip on a wedge or wood and see if you like first compared to the standard grip in respect to ball flight and such. 

before you change grips, try to hit some clubs at a golf store simulator that has demo clubs with midsize grips. they may feel good at address but might change your shot pattern. most of the time if your finger nails dig into your palms they are too small. if only your right hand digs in , build up your right shaft area a few raps with tape. a good club repair man or qualified salesperson knows what to do.